Other drugs may interact with codeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Not all possible interactions are listed in this medication guide. How Codeine Interacts With Other Drugs. Like most medications, it’s important to be aware of the drugs you take alongside codeine. However, the drug is commonly prescribed with other substances and, in some cases, medications are sold that contain both codeine and other medications. The combination of codeine-based cough syrup, soda, alcohol, and hard candy became popular at raves, clubs, concerts, and other large social events filled with adolescents and young adults in the early 1990s. Accidentally mixing a potent prescription drug with alcohol is risky enough, but some people struggle with addiction to prescription drugs and may mix these with alcohol. Learn more about these specific prescription drugs and the dangers that can occur when mixing them with alcohol. Codeine and alcohol are both perilous drugs in their own right, even though alcohol is a part of daily life for many Americans. Because it is so commonplace, many don’t think twice about drinking while taking prescription medications like codeine. However, when used simultaneously, the two substance can prove lethal. Mixing alcohol and codeine, or any other combination of intoxicating substances, can lead to addiction and dependence. Thankfully, you can get help overcoming addiction and drug abuse before long-term harm occurs. Recovery is possible for anyone. Codeine is an opiate analgesic medication that is often prescribed for the treatment of pain or the reduction of cough. The drug may cause interactions when taken with other drugs so it’s important to talk with your doctor about any medications that you may be taking prior to taking codeine. Mixing Cocaine with Alcohol Mixing Heroin and Cocaine Avoid Any Drug Combinations Treatment for Addiction to Cocaine and Other Drugs Most people know cocaine is a stimulant that can make you feel alert, energetic, and elated. Do not use more than the recommended dose of codeine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor. Mixing marijuana with other depressants can cause the heart rate to decrease to a very low rate. It can also inhibit the user’s basic motor skills, making it difficult for them to think clearly, speak, or react appropriately to things around them.